Quote Originally Posted by Russ Jerome View Post
Whatever upper you buy, here is a short list:

.17 Remington
.204 Ruger
.222 Remington
.223 Remington
5.56 Nato
6mm X 45
7.62 X 39
6.5 Grendel
6.8 Rem. SPC
6mm PPC
Im missing several.

After buying my S&W AR-15/22 and holding the receiver in hand next to another alum lower (guess who I bought it from!) I can say Im confident these polymer lowers should handle any "AR-15" cartridge out there, cant call the stuff plasic anymore. Im gonna test one with a 6.8 Remington SPC for deer next winter myself.

When you look at potential uppers make sure you look only at AR15 uppers, not AR10 uppers (larger family based of the 308, Mr Stoners original design for the AR).
Thanks for fielding that question for me. Some lowers come marked "multi-cal", I am not sure what these are marked, I will ask tomorrow.